| Статус: | Completed |
| Фаза: | Phase 2 |
| Начало: | 1 сентября 2012 г. |
| Окончание: | 1 декабря 2017 г. |
| Описание: | Study of eculizumab ability to correct the reperfusion injury of the kidney allograft. |
| смотреть на ClinicalTrials.gov |
| Статус: | Unknown status |
| Фаза: | Phase 1/Phase 2 |
| Начало: | 1 октября 2011 г. |
| Окончание: | 1 ноября 2014 г. |
| Описание: | T regulatory cells (T regs) are responsible for immune tolerance in solid organ transplant patients. This study will evaluate the treatment of children with kidney transplants either with Campath and other immune system suppressing medications alone or in combination with injection of autologous CD4+CD25+CD127lowFoxP3+ T regulatory cells expanded ex vivo. The aim of this study is to develop a new strategy that will be more effective in preventing organ rejection and maintaining patient health. |
| смотреть на ClinicalTrials.gov |
| Статус: | Completed |
| Фаза: | не указано |
| Начало: | 1 апреля 2009 г. |
| Окончание: | 1 мая 2016 г. |
| Описание: | After alemtuzumab induction, followed with kidney transplantation, patients will be randomly assigned to receive either tacrolimus or cyclosporine microemulsion in combination with mycophenolates. Patients will be followed including protocol biopsy at 1, 12, 36, 60 month posttransplant, regular nuclein acid testing (NAT) for cytomegalovirus (CMV), Epstein-Barr virus (EBV) and BK virus (BKV) in urine and blood. The investigation is undertaken to clarify the reason for equal survival rates for patients on cyclosporine and tacrolimus despite the lower rejection rate on tacrolimus. |
| смотреть на ClinicalTrials.gov |